| Identification | Back Directory | [Name]
Arnolol | [CAS]
87129-71-3 | [Synonyms]
Arnolol
3-Amino-1-[4-(2-methoxyethyl)phenoxy]-3-methylbutan-2-ol
1-[4-(2-methoxyethyl)-phenoxy]-3-amino-3-methyl-butan-2-ol
2-Butanol, 3-amino-1-[4-(2-methoxyethyl)phenoxy]-3-methyl- | [Molecular Formula]
C14H23NO3 | [MDL Number]
MFCD00868795 | [MOL File]
87129-71-3.mol | [Molecular Weight]
253.34 |
| Hazard Information | Back Directory | [Originator]
Arnolol,ZYF Pharm Chemical | [Uses]
Arnolol is a beta blocker with a pressure-lowering action[1]. | [Manufacturing Process]
2 methods of producing of 1-[4-(2-methoxyethyl)-phenoxy]-3-amino-3-
methyl-butan-2-ol:
1). 19.0 g of 1-[4-(2-methoxyethyl)phenoxy]-3-nitro-3-methylbutan-2-ol are
hydrogenated at 60°C and under a pressure of 6 bar in a mixture of 250 ml of
ethanol and 50 ml of glacial acetic acid in the presence of 4.0 g of palladiumon-
charcoal (10% Pd). After the mixture has been filtered and the solvent has
been evaporated off, the residue is rendered alkaline with 2 N NaOH and the mixture is extracted with CH2Cl2. The organic phase is washed with water and
dried with Na2SO4 to give, after evaporation, 15.0 g of the 1-[4-(2-
methoxyethyl)phenoxy]-3-amino-3-methylbutan-2-ol, melting point 120°-
122°C (dec.).
2). 18.3 g of zinc dust are gradually added to 20.0 g of 1-[4-(2-methoxyethyl)
phenoxy]-3-nitro-3-methylbutan-2-ol in 400 ml of ethanol and 60 ml of
concentrated hydrochloric acid at 50°-60°C. The mixture is stirred at this
temperature for 1 h and filtered and the solvent is evaporated off. After 200
ml of 40% strength NaOH have been added, the product is extracted with
methylene chloride. Solvent is distilled and the 1-[4-(2-methoxyethyl)
phenoxy]-3-amino-3-methylbutan-2-ol is produced, melting point 120°-122°C
(dec.). | [Therapeutic Function]
Beta-adrenergic blocker (ophthalmic) | [References]
[1] P Ashton, et al. The effect of chlorhexidine acetate on the corneal penetration of sorbitol from an arnolol formulation in the albino rabbit. J Ocul Pharmacol. 1990 Spring;6(1):37-42. DOI:10.1089/jop.1990.6.37 |
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| Company Name: |
Leancare Ltd.
|
| Tel: |
+33 962096793 |
| Website: |
www.leancare.co.uk |
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