| Identification | Back Directory | [Name]
Fevipiprant | [CAS]
872365-14-5 | [Synonyms]
QAW039
CS-2449
Fevipipran
NVP-QAW039
Fevipiprant
NVP-QAW039;QAW039
Fevipiprant (QAW039)
Fevipiprant(NVP-QAW039)
NVP-QAW039; QAW039;QAW039;QAW-039;QAW 039;FEVIPIPRANT
NVP-QAW039; NVP-QAW 039; NVP-QAW-039 QAW-039; QAW039; QAW 039; FEVIPIPRANT
2-Methyl-1-[[4-(methylsulfonyl)-2-(trifluoromethyl)phenyl]methyl]-1H-pyrrolo[2,3-b]pyridine-3-acetic acid
1H-Pyrrolo[2,3-b]pyridine-3-acetic acid, 2-methyl-1-[[4-(methylsulfonyl)-2-(trifluoromethyl)phenyl]methyl]- | [Molecular Formula]
C19H17F3N2O4S | [MDL Number]
MFCD22548206 | [MOL File]
872365-14-5.mol | [Molecular Weight]
426.41 |
| Chemical Properties | Back Directory | [Boiling point ]
637.6±55.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/mL; DMF:PBS(pH7.2) (1:2): 0.33 mg/mL; DMSO: 10 mg/mL; Ethanol: 1 mg/mL | [form ]
A crystalline solid | [pka]
3.33±0.30(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C19H17F3N2O4S/c1-11-15(9-17(25)26)14-4-3-7-23-18(14)24(11)10-12-5-6-13(29(2,27)28)8-16(12)19(20,21)22/h3-8H,9-10H2,1-2H3,(H,25,26) | [InChIKey]
GFPPXZDRVCSVNR-UHFFFAOYSA-N | [SMILES]
C12N(CC3=CC=C(S(C)(=O)=O)C=C3C(F)(F)F)C(C)=C(CC(O)=O)C1=CC=CN=2 |
| Hazard Information | Back Directory | [Uses]
Fevipiprant is used in the oral treatment of asthma and has been successful in targeting severe eosinophilic asthma.Fevipiprant is a novel oral prostaglandin D2 receptor 2 (DP2; known as CRTh2) antagonist and currently in development for the treatment of severe asthma and atopic dermatitis. | [in vivo]
Fevipiprant (10 mg/kg; in the drinking water) reduces CaCl2-induced AAA (abdominal aortic aneurysm) formation in mouse[3]. | Animal Model: | C57Bl/6 mice[3] | | Dosage: | 10 mg/kg | | Administration: | In the drinking water | | Result: | Efficiently reduced CaCl2-induced AAA formation with diminished elastin degradation, aortic macrophage infiltration, MPO accumulation and MCP-1 expression. |
| [IC 50]
DP2: 1.14 nM (Kd) | [storage]
Store at -20°C |
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