| Identification | Back Directory | [Name]
3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl- | [CAS]
875634-01-8 | [Synonyms]
PPY A
5-[3-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylpyridine-3-carboxamide
5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide
3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl- | [Molecular Formula]
C22H20N4O2 | [MDL Number]
MFCD18642591 | [MOL File]
875634-01-8.mol | [Molecular Weight]
372.42 |
| Hazard Information | Back Directory | [Uses]
PPY-A is a potent T315I mutant and wild-type Abl kinases inhibitor with IC50s of 9 and 20 nM, respectively. PPY-A inhibits Ba?F3 cells transformed with wild-type Abl and Abl T315I mutantl with IC50s of 390 and 180 nM, respectively. PPY-A can be used for the research of chronic myeloid leukemia (CML)[1]. | [storage]
Store at -20°C | [References]
[1] Tianjun Zhou, et al. Crystal structure of the T315I mutant of AbI kinase. Chem Biol Drug Des. 2007 Sep;70(3):171-81. DOI:10.1111/j.1747-0285.2007.00556.x |
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