| Identification | Back Directory | [Name]
1-(4-Chlorophenyl)-3-[3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl]urea | [CAS]
877202-74-9 | [Synonyms]
PSNCBAM 1
PSNCBAM-1 >=98% (HPLC)
PSNCBAM-1,PSNCBAM1,inhibit,Inhibitor,Cannabinoid Receptor
1-(4-Chlorophenyl)-3-[3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl]urea
N-(4-Chlorophenyl)-N′-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]-urea
Urea, N-(4-chlorophenyl)-N'-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]- | [Molecular Formula]
C22H21ClN4O | [MDL Number]
MFCD12756395 | [MOL File]
877202-74-9.mol | [Molecular Weight]
392.88 |
| Chemical Properties | Back Directory | [Boiling point ]
521.5±50.0 °C(Predicted) | [density ]
1.332 | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble15mg/mL (clear solution) | [form ]
powder | [pka]
13.45±0.70(Predicted) | [color ]
white to beige | [InChI]
1S/C22H21ClN4O/c23-17-9-11-18(12-10-17)24-22(28)25-19-6-3-5-16(15-19)20-7-4-8-21(26-20)27-13-1-2-14-27/h3-12,15H,1-2,13-14H2,(H2,24,25,28) | [InChIKey]
HDAYFSFWIPRJSO-UHFFFAOYSA-N | [SMILES]
Clc1ccc(NC(=O)Nc2cccc(c2)-c3cccc(n3)N4CCCC4)cc1 |
| Hazard Information | Back Directory | [Uses]
PSNCBAM-1 is a selective CB1 receptor allosteric antagonist with an EC50 of 0.1 μM. PSNCBAM-1 can be used in the researches of obesity[1]. | [Biological Activity]
PSNCBAM-1 is an allostericnon-competitive antagonist of CB-1. The compound blocks the effects of WIN 55212-2 and CP55940and reduces food intake and weight gain in rats. | [IC 50]
hCB1-R: 0.1 μM (EC50) | [storage]
Store at +4°C | [References]
[1] Horswill JG, et al. PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br J Pharmacol. 2007 Nov;152(5):805-14. DOI:10.1038/sj.bjp.0707347 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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