| Identification | Back Directory | [Name]
Azido-PEG10-alcohol | [CAS]
877239-09-3 | [Synonyms]
Azido-PEG9-OH
CAS_877239-09-3
Azido-PEG10-alcohol | [Molecular Formula]
C20H41N3O10 | [MDL Number]
MFCD22683293 | [MOL File]
877239-09-3.mol | [Molecular Weight]
483.56 |
| Hazard Information | Back Directory | [Description]
Azido-PEG10-alcohol is a aqueous soluble linker regent containing an click chemistry azide group and a terminal hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. | [Uses]
Azido-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG10-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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