| Identification | Back Directory | [Name]
Azido-PEG11-amine | [CAS]
1800414-71-4 | [Synonyms]
N3-PEG11-NH2
Azido-PEG11-NH2
Azido-PEG11-amine
Amino-PEG12-azide
35-Amino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontanyl Azide
35-Azido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-amine
1-Amino-35-azido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontane | [Molecular Formula]
C24H50N4O11 | [MDL Number]
MFCD08274605 | [MOL File]
1800414-71-4.mol | [Molecular Weight]
570.68 |
| Hazard Information | Back Directory | [Description]
Azido-PEG11-amine is a water soluble PEG compound. The azide group enables Click Chemistry. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG arm increases solubility in aqueous media. | [Uses]
Azido-PEG11-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG11-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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