| Identification | More | [Name]
2-Bromo-1-ethylpyridinium tetrafluoroborate | [CAS]
878-23-9 | [Synonyms]
2-BROMO-1-ETHYLPYRIDINIUM TETRAFLUOROBORATE
BEP TETRAFLUOROBORATE
bromoethylpyridiniumtetrafluoroborate
BEPyBr
2-BROMO-1-ETHYLPYRIDINIUM TETRAFLUOROBORATE (BEP)
2-Bromo-1-ethylpyridinium tetrafluoroborate 98%
2-Bromo-1-ethylpyridiniumtetrafluoroborate98%
2-BROMO-1-ETHYLPYRIDINIUM TETRAFLUOROBOR
1-Ethyl-2-bromopyridinium·tetrafluoroborate
1-Ethyl-2-bromopyridinium·tetrafluoroboronanion | [EINECS(EC#)]
212-900-2 | [Molecular Formula]
C7H9BBrF4N | [MDL Number]
MFCD00060046 | [Molecular Weight]
273.86 | [MOL File]
878-23-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
103-107 °C | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
Crystalline Powder | [color ]
White | [Water Solubility ]
very faint turbidity | [BRN ]
4059265 | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C7H9BrN.BF4/c1-2-9-6-4-3-5-7(9)8;2-1(3,4)5/h3-6H,2H2,1H3;/q+1;-1 | [InChIKey]
YJDXVQLBIAJTHP-UHFFFAOYSA-N | [SMILES]
[N+]1(CC)C=CC=CC=1Br.[B-](F)(F)(F)F | [CAS DataBase Reference]
878-23-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
1759 | [WGK Germany ]
3
| [F ]
9-21 | [Hazard Note ]
Irritant | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29333990 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Uses]
2-Bromo-1-ethyl-pyridinium tetrafluoroborate can be used as a coupling reagent for:
- The synthesis of N-methylated peptides in solution and solid phase.
- The synthesis of cyclosporin A fragment and dolastatin 15 pentapeptide moiety.
| [Uses]
2-Bromo-1-ethylpyridinium Tetrafluoroborate is a carboxyl activation and coupling reagent for peptide synthesis. | [General Description]
2-Bromo-1-ethyl-pyridinium tetrafluoroborate is a coupling reagent employed in the synthesis of amides and esters through amidation and esterification reactions, respectively. It is generally prepared by the reaction of triethyloxonium tetrafluoroborate with 2?bromo pyridine. | [reaction suitability]
reaction type: Coupling Reactions | [Synthesis]
Procedure: trifluoroacetic acid (9.2 ml, 12.0 mg molecule) was added to a solution (3.00 g, 12.0 mg molecule) of N-Boc-N-methyl-L-leucine methyl ester (50 ml) at -20°C. This mixture was heated to room temperature and stirred for 2 h. The aqueous layer was |
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