| Identification | Back Directory | [Name]
5,7-DIMETHOXY-INDAN-1-ONE | [CAS]
880-87-5 | [Synonyms]
5,7-Dimethoxy-1-indanone
5,7-DIMETHOXY-INDAN-1-ONE
5,7-dimethoxy-2,3-dihydroinden-1-one
2,3-Dihydro-5,7-dimethoxy-1H-inden-1-one
5,7-diMethoxy-2,3-dihydro-1H-inden-1-one
1H-Inden-1-one, 2,3-dihydro-5,7-dimethoxy- | [Molecular Formula]
C11H12O3 | [MDL Number]
MFCD02684971 | [MOL File]
880-87-5.mol | [Molecular Weight]
192.21 |
| Chemical Properties | Back Directory | [Melting point ]
99-100 °C | [Boiling point ]
352.6±42.0 °C(Predicted) | [density ]
1.34 g/cm3 | [storage temp. ]
Sealed in dry,Room Temperature | [Appearance]
Off-white to light yellow Solid |
| Questions And Answer | Back Directory | [Uses]
5,7-Dimethoxyindan-1-one acts as a reagent for the preparation and antitumor activities of phenyl- and benzothiazolylisoquinolinedienes. |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 5,7-dimethoxyindanone from 3,5-dimethoxyphenylpropionic acid was as follows: 3-(3,5-dimethoxyphenyl)propionic acid (2 g x 5) was dissolved in methanesulfonic acid (10 ml x 5) in a microwave treated vial (20 ml x 5). The reaction mixture was heated at 90°C for 10 min under microwave radiation. After completion of the reaction, the mixture was slowly poured into ice (250 g) and neutralized to pH 8-9 with 2 M NaOH solution, followed by extraction with EtOAc. The organic layers were combined and the target product 5,7-dimethoxyindanone (8.8 g, 96.2% yield) was obtained after concentration. The product was analyzed by LC-MS and showed m/e 193 (MH+). | [References]
[1] Chemistry - An Asian Journal, 2015, vol. 10, # 4, p. 1050 - 1064
[2] Tetrahedron, 2007, vol. 63, # 2, p. 389 - 395
[3] Patent: WO2007/71348, 2007, A1. Location in patent: Page/Page column 87
[4] ChemMedChem, 2018, vol. 13, # 18, p. 1949 - 1956
[5] Tetrahedron Letters, 1980, vol. 21, # 37, p. 3603 - 3606 |
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