| Identification | More | [Name]
DL-CATECHIN | [CAS]
88191-48-4 | [Synonyms]
(2S,3R)-2-(3,4-DIHYDROXYPHENYL)-3,4-DIHYDRO-2H-1-PYRAN-3,5,7-TRIOL
(+/-)-3,3',4',5,7-FLAVANPENTOL
3,3',4',5,7-FLAVANPENTOL
3,5,7,3',4'-PENTAHYDROXYFLAVANE
(+/-)-CATECHIN
CATECHIN
CATECHIN, DL-
CATECHINS
CATECHU
(-)-CYANIDANOL-3
DL-CATECHIN
DL-CATECHIN CATECHINS
TRANS-1,2,4,5-BENZENETETRACARBOXYLIC ACID
TRANS-2-(3,4-DIHYDROXYPHENYL)3,4-DIHYDRO-2H-1-BENZOPYRAN-3,5,7-TRIOL
TRANS-PYROMELLITIC ACID | [Molecular Formula]
C15H14O6 | [MDL Number]
MFCD00135995 | [Molecular Weight]
290.27 | [MOL File]
88191-48-4.mol |
| Hazard Information | Back Directory | [Uses]
Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. | [Definition]
ChEBI: The monohydrate of (+)-catechin. | [in vivo]
Animals treated with Catechin at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with Catechin prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively)[3]. | [IC 50]
COX-1: 1.4 μM (IC50) | [References]
[1] Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9. DOI:10.1207/S15327914NC402_14
[2] Alshatwi AA. Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. J Exp Clin Cancer Res. 2010 Dec 17;29:167. DOI:10.1186/1756-9966-29-167
[3] Cheruku SP, et al. Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats. Cytotechnology. 2018 Feb;70(1):245-259. DOI:10.1007/s10616-017-0138-8 |
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