| Identification | Back Directory | [Name]
ST072042 | [CAS]
88349-90-0 | [Synonyms]
A2793
ST072042
ethyl [(5-chloroquinolin-8-yl)oxy]acetate
ethyl 2-(5-chloroquinolin-8-yl)oxyacetate
ethyl 2-[(5-chloro-8-quinolyl)oxy]acetate
ethyl 2-(5-chloroquinolin-8-yl)oxyethanoate
2-[(5-chloro-8-quinolyl)oxy]acetic acid ethyl ester
Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-, ethyl ester | [Molecular Formula]
C13H12ClNO3 | [MDL Number]
MFCD04275530 | [MOL File]
88349-90-0.mol | [Molecular Weight]
265.69 |
| Chemical Properties | Back Directory | [Boiling point ]
393.4±27.0 °C(Predicted) | [density ]
1.291±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mg/mL (376.38 mM) | [form ]
Solid | [pka]
1.97±0.29(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
A2793 is an efficient dual TWIK-related acid-sensitive K+ channel (TASK)-1/TRESK inhibitor, with an IC50 of 6.8 μM for mTRESK. A2764 is more selective for TRESK, and it only moderately influences TREK-1 and TALK-1[1]. | [Biological Activity]
A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is a TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK . | [in vitro]
A2793 (100 μM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5).
It inhibits TASK-1 (100 μM, 53.4±13,5%, n=5), while A2764 is more selective for TRESK, it only moderately influences TREK-1 and TALK-1.
A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1.
| [target]
| Target | Value | mTRESK
(Cell-free assay) | 6.8 μM |
| [References]
[1] Miklós Lengyel, et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K 2P 18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660. DOI:10.1124/mol.118.115626 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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