| Identification | Back Directory | [Name]
Ketone, 3-isothiazolyl methyl (7CI) | [CAS]
88511-35-7 | [Synonyms]
1-(Isothiazol-3-yl)ethanone
Ethanone, 1-(3-isothiazolyl)-
1-(Isothiazol-3-yl)ethan-1-one
1-(1,2-Thiazol-3-yl)ethan-1-one
Ketone, 3-isothiazolyl methyl (7CI) | [Molecular Formula]
C5H5NOS | [MDL Number]
MFCD24698632 | [MOL File]
88511-35-7.mol | [Molecular Weight]
127.16 |
| Hazard Information | Back Directory | [Uses]
1-(Isothiazol-3-yl)ethan-1-one (Q11) is a CYP2E1 inhibitor. 1-(Isothiazol-3-yl)ethan-1-one can be used in rheumatoid arthritis and sepsis related research[1]. | [IC 50]
CYP2E1 | [References]
[1] Han Z,et al. Discovery of CYP2E1 as a novel target in rheumatoid arthritis and validation by a new specific CYP2E1 inhibitor. Biochem Pharmacol. 2024 Aug 20;229:116501. DOI:10.1016/j.bcp.2024.116501
[2] Gao N, et al. The CYP2E1 inhibitor Q11 ameliorates LPS-induced sepsis in mice by suppressing oxidative stress and NLRP3 activation. Biochem Pharmacol. 2023 Aug;214:115638. DOI:10.1016/j.bcp.2023.115638 |
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