| Identification | Back Directory | [Name]
RUDVTXZKYPJLFH-ZZVYKPCYSA-N | [CAS]
887927-59-5 | [Synonyms]
RUDVTXZKYPJLFH-ZZVYKPCYSA-N
(+)-2,5-epi Goniothalesdiol Exclusive
Methyl 3-((2R,3S,4S,5S)-3,4-dihydroxy-5-phenyltetrahydrofuran-2-yl)propanoate | [Molecular Formula]
C14H18O5 | [MOL File]
887927-59-5.mol | [Molecular Weight]
266.29 |
| Chemical Properties | Back Directory | [Boiling point ]
429.5±45.0 °C(Predicted) | [density ]
1.256±0.06 g/cm3(Predicted) | [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: Miscible; PBS (pH 7.2): 5 mg/ml | [pka]
13.59±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Goniothalesdiol, isolated from the bark of the Malaysian tree G. borneensis, is a tetrahydrofuran compound known to have significant cytotoxic effects against P388 murine leukemia cells and pesticidal activities.1,2 (+)-2,5-epi-Goniothalesdiol is a goniothalesdiol analog.3 Little is known of its biological activity. | [Uses]
(+)-2,5-epi-Goniothalesdiol is an analogue of Goniothalesdiol, which exhibits significant cytotoxicity against P388 mouse leukemia cells and has insecticidal activity. (+)-2,5-epi-Goniothalesdiol can be synthesized starting from D-mannitol (HY-N0378)[1]. | [References]
1. Prasad, K.R., and Gholap, S.L. An expeditious enantiospecific total synthesis of (+)-7-epi-goniofufurone Synlett 14,2260-2262(2005).
2. Blázquez, M.A., Bermejo, A., Zafra-Polo, M.C., et al. Styryl-lactones from Goniothalamus species-a review Phytochem. Anal. 10(4),161-170(1999).
3. Prasad, K.R., and Gholap, S.L. Stereoselective synthesis of (+)-goniothalesdiol J. Org. Chem. 71(9),3643-3645(2006). |
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