| Identification | Back Directory | [Name]
Propargyl-PEG4-CH2CO2tBu | [CAS]
888010-02-4 | [Synonyms]
Alkyne-PEG4-CH2COOtBu
Propargyl-PEG3-OCH2-Boc
Propargyl-PEG3-CH2COOtBu
PROPARGYL-PEG4-CH2COOTBU
Propargyl-PEG4-CH2CO2tBu
Propargyl-PEG3-t-butyl acetate
tert-butyl 3,6,9,12-tetraoxapentadec-14-ynoate
tert-butyl-2-(2-{2-[2-(prop-2-ynyloxy)ethoxy]ethoxy}ethoxy)acetate | [Molecular Formula]
C15H26O6 | [MDL Number]
MFCD28122944 | [MOL File]
888010-02-4.mol | [Molecular Weight]
302.36 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG4-CH2CO2tBu is a PEG reagent that can reacts with azide compounds or biomolecules under the catalyzation of copper. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Propargyl-PEG3-OCH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-OCH2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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