| Identification | Back Directory | [Name]
Propargyl-PEG5-tetra-Ac-beta-D-galactose | [CAS]
1397682-61-9 | [Synonyms]
Propargyl-PEG5-tetra-Ac-beta-D-galactose
Propargyl-PEG4-tetra-Ac-beta-D-galactose | [Molecular Formula]
C25H38O14 | [MDL Number]
MFCD31692197 | [MOL File]
1397682-61-9.mol | [Molecular Weight]
562.57 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG5-tetra-Ac-beta-D-galactose is a Click Chemistry-ready crosslinker containing a propargyl group and beta-D-galactose. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. D-galactose increases solubility in aqueous media and a the selectivity of the PEGlation reaction. | [Uses]
Propargyl-PEG4-tetra-Ac-beta-D-galactose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|