| Identification | Back Directory | [Name]
3-BROMO-6-CHLOROPYRIDAZINE | [CAS]
89089-18-9 | [Synonyms]
3-Brom-6-chlorpyridazin
3-BROMO-6-CHLOROPYRIDAZINE
Pyridazine,3-bromo-6-chloro
3-bromanyl-6-chloranyl-pyridazine
3-BROMO-6-CHLOROPYRIDAZINE ISO 9001：2015 REACH | [EINECS(EC#)]
200-001-2 | [Molecular Formula]
C4H2BrClN2 | [MDL Number]
MFCD09834814 | [MOL File]
89089-18-9.mol | [Molecular Weight]
193.429 |
| Questions And Answer | Back Directory | [Synthesis]
At -10 °C, sodium nitrite (4.18 g, 60.7 mmol) in water (6 mL) was added to a 48% HBr solution of 3-amino-6-chloropyridazine (3.0 g, 23.3 mmol). Bromine (11.2 g, 3 eq) was slowly added, and the reaction was stirred at room temperature for 48 hours. A solution of NaOH (16.8 g) in water (42 mL) was added, and the organic layer was extracted with Et2O, dried over Na2SO4, and evaporated. The title compound was given as a white solid in 44% yield after rapid chromatographic purification using DCM/cyclohexane 50/50 as eluent. 
| [Application]
3-Bromo-6-chloropyridazine is an organic intermediate that can be obtained by diazotization and bromination of 3-amino-6-chloropyridazine. |
| Chemical Properties | Back Directory | [Melting point ]
93.5-94 °C(Solv: ligroine (8032-32-4)) | [Boiling point ]
300.8±22.0 °C(Predicted) | [density ]
1.859±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
-1.48±0.10(Predicted) |
|
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