| Identification | Back Directory | [Name]
4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID& | [CAS]
89238-99-3 | [Synonyms]
4-Methoxybenzyl trichloroacetimidate
4-Methoxybenzyl trichloroacetamidate
4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID&
4-Methoxybenzyl 2,2,2-Trichloroacetimidate
4-methoxybenzyl 2,2,2-trichloroethanimidoate
4-Methoxybenzyl2,2,2-Trichloroacetimidate>
2,2,2-Trichloroacetimidic Acid 4-Methoxybenzyl Ester
2,2,2-trichlorohydrin-4-methoxybenzyl ester per acetic acid
Ethanimidic acid, 2,2,2-trichloro-, (4-methoxyphenyl)methyl ester | [Molecular Formula]
C10H10Cl3NO2 | [MDL Number]
MFCD00134547 | [MOL File]
89238-99-3.mol | [Molecular Weight]
282.55 |
| Chemical Properties | Back Directory | [Boiling point ]
137 °C / 0.7mmHg | [density ]
1.361 g/mL at 25 °C | [refractive index ]
n20/D 1.5488 | [Fp ]
110 °C | [storage temp. ]
Refrigerator | [form ]
clear liquid | [pka]
1.96±0.70(Predicted) | [color ]
Colorless to Light yellow to Light orange | [InChI]
InChI=1S/C10H10Cl3NO2/c1-15-8-4-2-7(3-5-8)6-16-9(14)10(11,12)13/h2-5,14H,6H2,1H3 | [InChIKey]
TYHGKLBJBHACOI-UHFFFAOYSA-N | [SMILES]
C(=N)(OCC1=CC=C(OC)C=C1)C(Cl)(Cl)Cl |
| Hazard Information | Back Directory | [Uses]
4-Methoxybenzyl-2,2,2-trichloroacetimidate can be used as a reagent for the protection of alcohols as the p-methoxybenzyl ether. 1o, 2o, and 3o alcohols can be easily protected using this reagent with equal efficiency in the presence of a variety of different protective groups. This reagent is commonly used under acidic conditions therefore it offers an alternative method to the Williamson ether synthesis, which is typically used basic conditions to protect base-sensitive alcohols. | [reaction suitability]
reaction type: Fmoc solid-phase peptide synthesis |
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