| Hazard Information | Back Directory | [Description]
JNJ-28583867 is a histamine H(3) receptor antagonist and serotonin reuptake inhibitor. | [Uses]
JNJ-28583867 is an orally active and selective histamine H3 receptor antagonist (Ki=10.6 nM) and serotonin transporter (SERT) inhibitor (Ki=3.7 nM). JNJ-28583867 can be used in the research of depression[1]. | [IC 50]
H3 receptor: 10.6 nM (Ki) | [References]
[1] Barbier A J, et al. Pharmacological characterization of JNJ-28583867, a histamine H3 receptor antagonist and serotonin reuptake inhibitor[J]. European journal of pharmacology, 2007, 576(1-3): 43-54. DOI:10.1016/j.ejphar.2007.08.009 |
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