| Identification | Back Directory | [Name]
LDN-212320 | [CAS]
894002-50-7 | [Synonyms]
LDN-212320
LDN-0212320
OSU-0212320
LDN/OSU-0212320
LDN/OSU-0212320;LDN-0212320;OSU-0212320
3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazine
(3-[(2-methylbenzyl)sulfenyl]-6-(pyridine-2-yl)pyridazine)
3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine
Pyridazine, 3-[[(2-methylphenyl)methyl]thio]-6-(2-pyridinyl)- | [Molecular Formula]
C17H15N3S | [MDL Number]
MFCD05960679 | [MOL File]
894002-50-7.mol | [Molecular Weight]
293.39 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (170.42 mM; Need ultrasonic) | [form ]
Powder | [color ]
White to gray | [InChI]
InChI=1S/C17H15N3S/c1-13-6-2-3-7-14(13)12-21-17-10-9-16(19-20-17)15-8-4-5-11-18-15/h2-11H,12H2,1H3 | [InChIKey]
DUUQLWDHNYFUPP-UHFFFAOYSA-N | [SMILES]
C1(SCC2=CC=CC=C2C)=NN=C(C2=NC=CC=C2)C=C1 |
| Hazard Information | Back Directory | [Uses]
LDN 212320 is a small molecule activator of glutamate transporter EAAT2 translation, which provides neuroprotection and shows potential for the therapeutic treatment of neurodegenerative diseases. | [in vivo]
LDN-212320 (10 or 20 mg/kg, i.p) significantly attenuates formalin-evoked nociceptive behavior[1].
LDN-212320 (10 or 20 mg/kg, i.p) significantly reverses formalin-induced impaired hippocampal-dependent behavior. In addition, LDN-212320 (10 or 20 mg/kg, i.p) increases GLT-1 expressions in the hippocampus and ACC[1].
LDN-212320 (20 mg/kg, i.p) significantly reduced formalin induced-ERK phosphorylation, a marker of nociception, in the hippocampus and ACC[1].
| Animal Model: | Mice[1]. | | Dosage: | 10 or 20 mg/kg. | | Administration: | IP 24 h before the injection of formalin. | | Result: | Significantly attenuated licking and biting behavior during both phases 1 and 2 in a dose-dependent manner compared to formalin-injected mice.
Significantly (P < 0.01 or P < 0.001) reduced the licking and biting behavior.
Significantly increased preference for the displaced object (F3, 13 = 28.03, P < 0.01) compared to formalin-injected mice.
Significantly (P < 0.001) increased interaction time with the displaced object compared to formalin-injected mice.
|
| [IC 50]
EAAT2 | [storage]
Store at -20°C |
|
| Company Name: |
Lynnchem
|
| Telephone: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Twochem Co.Ltd.
|
| Telephone: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|