| Identification | Back Directory | [Name]
MSX-122 | [CAS]
897657-95-3 | [Synonyms]
MSX-122
MSX 222
CS-2430
MSX-122;MSX122
MSX-122;MSX 122;MSX122
1,4-Benzenedimethanamine, N1,N4-di-2-pyrimidinyl-
N-[[4-[(pyrimidin-2-ylamino)methyl]phenyl]methyl]pyrimidin-2-amine | [Molecular Formula]
C16H16N6 | [MDL Number]
MFCD18803971 | [MOL File]
897657-95-3.mol | [Molecular Weight]
292.35 |
| Chemical Properties | Back Directory | [Melting point ]
219 °C | [Boiling point ]
566.9±60.0 °C(Predicted) | [density ]
1.313±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO:0.2(Max Conc. mg/mL);0.7(Max Conc. mM) | [form ]
A crystalline solid | [pka]
3.82±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
CXCR4 is involved with the recruitment of inflammatory cells to inflammation sites. MSX-122 is a CXCR4 inhibitor. It exhibits potential antineoplastic and antiviral activities. | [in vivo]
MSX-122 (10 mg/kg, i.p.) blocks inflammation induced by carrageenan and lung fibrosis induced by bleomycin in mice. MSX-122 (4 mg/kg, i.p., daily) blocks metastasis in an experimental animal model of breast cancer metastasis. Furthermore, MSX-122 (10 mg/kg i.p., daily) significantly decreases the numbers of hepatic micrometastases[1]. | [IC 50]
CXCR4/CXCL12: ~10 nM (IC50) |
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