| Identification | More | [Name]
5-(Ethylthio)-1H-tetrazole | [CAS]
89797-68-2 | [Synonyms]
5-ETHYLSULFANYL-1H-TETRAZOLE
5-(ETHYLTHIO)TETRAZOLE
5-(S-ETHYLMERCAPTO)-TETRAZOLE
ACTIVATOR
ACTIVATOR REAGENT
ETT
5-(ethvlthio)-1h-tetrazole
5-(Ethylthio)-1H-tetrazole solution, 0.25M in acetonitrile
5-ETHYLTHIO-1H-TETRAZOLE 99%
5-Ethylthio-1H-Tetrazole(Ett)
ETT(0.25 M in acetonitrile)
5-EETHYLTHIO-1H-TETRAZOLE (ETT)
5-ETHYLTHIOL-1H-TETRAZOLE
1H-Tetrazole,5-(ethylthio)-(9CI)
5-Ethyltio-1H-Tetrazole
5-(Ethylmercapto)-1H-tetrazole
5-ETHYLTIO-1H-TETRAZOLE 99%MIN
1H-TETRAZOLE,5-(ETHYLTHIO)
5-ETHYLTHIO-1H-TETRAZOLE, 99%MIN.
5-Ethylthio-IH-tetrazole | [EINECS(EC#)]
-0 | [Molecular Formula]
C3H6N4S | [MDL Number]
MFCD00068733 | [Molecular Weight]
130.17 | [MOL File]
89797-68-2.mol |
| Chemical Properties | Back Directory | [Appearance]
White crystals | [Melting point ]
72-80 °C(lit.)
| [Boiling point ]
81-82 °C
| [density ]
0.786 g/mL at 25 °C
| [Fp ]
42 °F
| [storage temp. ]
Store at 0-5°C | [solubility ]
soluble, clear, colorless | [form ]
buffered aqueous solution | [pka]
3.89±0.10(Predicted) | [color ]
solid white | [biological source]
rabbit | [InChI]
InChI=1S/C3H6N4S/c1-2-8-3-4-6-7-5-3/h2H2,1H3,(H,4,5,6,7) | [InChIKey]
GONFBOIJNUKKST-UHFFFAOYSA-N | [SMILES]
N1=C(SCC)N=NN1 | [CAS DataBase Reference]
89797-68-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
  
GHS02,GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H225-H302+H312+H332-H315-H318 | [Precautionary statements ]
P210-P280-P301+P312-P303+P361+P353-P304+P340+P312-P305+P351+P338 | [Hazard Codes ]
Xi,Xn,F | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R44:Risk of explosion if heated under confinement.
R36:Irritating to the eyes.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S35:This material and its container must be disposed of in a safe way .
S36/37:Wear suitable protective clothing and gloves .
S16:Keep away from sources of ignition-No smoking .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 1648 3/PG 2
| [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
4.1 | [PackingGroup ]
III | [HS Code ]
29339900 | [Storage Class]
4.1A - Other explosive hazardous materials | [Hazard Classifications]
Eye Dam. 1
Skin Corr. 1B
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystals | [Uses]
- Solid-Phase Synthesis of Symmetrical Dinucleoside Phosphodiesters: Explores the efficiency of 5-(Ethylthio)-1H-tetrazole in the solid-phase synthesis of dinucleoside phosphodiesters, underlining its significance in the streamlined production of biologically relevant molecules (Ahmadibeni et al., 2007).
- Synthesis, Deprotection, Analysis, and Purification of RNA and Ribozymes: Utilizes 5-(Ethylthio)-1H-tetrazole in the synthesis and processing of RNA and ribozymes, highlighting its critical role in molecular biology and genetic engineering research (Wincott et al., 1995).
| [Application]
5-(Ethylthio)-1H-tetrazole is used a powerful activator in DNA and RNA syntheses. | [Preparation]
5-(Ethylthio)-1H-Tetrazole is prepared from the corresponding alkyl thiocyanate and sodium azide through a [2?+?3] cycloaddition under phase transfer catalytic conditions (eq 1). The ratio of the solvent (water to toluene) as well as the reaction temperature are important factors in obtaining preparative yields of the alkylthiotetrazoles. 5-Ethylthio-1H-tetrazole has also been prepared using DMF as solvent albeit in much lower yield.
 | [General Description]
5-(Ethylthio)-1H-tetrazole (ETT) is an efficient activator, that activates nucleoside phosphoramidites towards condensation with a nucleoside to form dinucleoside phosphates during oligonucleotide synthesis. | [Purification Methods]
recrystallized from toluene. |
|
| Company Name: |
Nanjing Searchem Co., Ltd. Gold
|
| Telephone: |
15105140861 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList1730952/0_EN.htm |
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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