| Identification | Back Directory | [Name]
2-AMINO-5-BROMO-4 6-DIMETHYLPYRIDINE& | [CAS]
89856-44-0 | [Synonyms]
6-Amino-3-bromo-2,4-iutidine
3-Bromo-2,4-dimethylpyridin-6-amine
5-BroMo-4,6-diMethylpyridin-2-aMine
5-bromo-4,6-dimethyl-2-pyridinamine
6-Amino-2,4-dimethyl-3-bromopyridine
2-AMino-4,6-diMethyl-5-broMopyridine
2-Pyridinamine, 5-bromo-4,6-dimethyl-
2-AMino-5-broMo-4,6-diMethylpyridine 97%
2-AMINO-5-BROMO-4 6-DIMETHYLPYRIDINE& ISO 9001：2015 REACH
5-Bromo-4,6-dimethyl-2-pyridinamine, 6-Amino-3-bromo-2,4-lutidine | [EINECS(EC#)]
626-748-3 | [Molecular Formula]
C7H9BrN2 | [MDL Number]
MFCD00151793 | [MOL File]
89856-44-0.mol | [Molecular Weight]
201.06 |
| Chemical Properties | Back Directory | [Melting point ]
144-148 °C (lit.) | [Boiling point ]
257.7±35.0 °C(Predicted) | [density ]
1.504±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
soluble in Chloroform, Methanol | [form ]
Off-White to Pale Beige Solid | [pka]
5.46±0.48(Predicted) | [Appearance]
Off-white to yellow Solid | [InChIKey]
BFRMYMFNSHASRJ-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Chemical Properties]
White Powder | [Synthesis]
Example 2: Preparation of 2-amino-5-bromo-4,6-dimethylpyridine (13): 2.00 g (16.32 mmol) of 2-amino-4,6-dimethylpyridine was dissolved in 25 mL of acetonitrile under argon protection and 2.90 g (16.32 mmol) of N-bromosuccinimide was added with stirring. The reaction mixture was stirred at room temperature for 5 hours. Upon completion of the reaction, the resulting precipitate was collected by filtration and dried to afford the target product 2-amino-5-bromo-4,6-dimethylpyridine as a white solid in a yield of 2.76 g (84% yield). The structure of the product was confirmed by 1H-NMR (CDCl3) δ 6.22 (s, 1H), 4.39 (br, 2H), 2.48 (s, 3H), 2.25 (s, 3H) and 13C-NMR (CDCl3) δ 156.34, 155.23, 148.64, 112.26, 108.10, 25.10, 23.30. | [References]
[1] Organic Process Research and Development, 2012, vol. 16, # 1, p. 109 - 116
[2] Patent: WO2011/103536, 2011, A1. Location in patent: Page/Page column 43-44
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 17, p. 5188 - 5201
[4] Pharmacy and Pharmacology Communications, 1999, vol. 5, # 3, p. 233 - 238
[5] Patent: WO2018/108671, 2018, A1. Location in patent: Page/Page column 178; 179 |
|
|