| Identification | Back Directory | [Name]
3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANAL | [CAS]
89922-82-7 | [Synonyms]
3-TBDMSO-propionaldehyde
3-tert-Butyldimethylsiloxy)propanal
3-tert-Butyldimethylsilyloxypropanal
3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANAL
3-(tert-Butyldimethylsiloxy)propionaldehyde
3-t-Butyldimethylsilanyloxy Propionaldehyde
3-Tert-butyldiMethylsilyloxy)propionaldehyde
3-[Dimethyl(1,1-dimethylethyl)siloxy]propanal
3-(tert-Butyldimethylsiloxy)propionaldehyde 96%
3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]propanal
3-(TERT-BUTYL-DIMETHYL-SILANYLOXY)-PROPIONALDEHYDE
Propanal,3-[[(1,1-diMethylethyl)diMethylsilyl]oxy]- | [Molecular Formula]
C9H20O2Si | [MDL Number]
MFCD04039464 | [MOL File]
89922-82-7.mol | [Molecular Weight]
188.34 |
| Chemical Properties | Back Directory | [Appearance]
Brown Oil | [Boiling point ]
95 °C(Press: 23 Torr) | [density ]
0.892 g/mL at 25 °C | [refractive index ]
n20/D1.431 | [Fp ]
84℃ | [storage temp. ]
-20°C Freezer, Under Inert Atmosphere | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Oil | [color ]
Colourless to Pale Yellow | [InChI]
InChI=1S/C9H20O2Si/c1-9(2,3)12(4,5)11-8-6-7-10/h7H,6,8H2,1-5H3 | [InChIKey]
WGWCJTNWUFFGFH-UHFFFAOYSA-N | [SMILES]
C(=O)CCO[Si](C(C)(C)C)(C)C |
| Hazard Information | Back Directory | [Chemical Properties]
Brown Oil | [Uses]
3-[(tert-Butyldimethylsilyl)oxy]-1-propanal is useful for preparing EGFR inhibitors for the treatment of cancer. | [Preparation]
3-(tert-Butyldimethylsilyloxy)propanol (1.90 g, 10 mmol) was dissolved in dichloromethane (20 mL), and Dess-Martin reagent (6.36 g, 15 mmol) was added under ice bath. After stirring at room temperature for 4 hours, saturated aqueous sodium bicarbonate solution was added to quench, and the mixture was diluted with dichloromethane (100 mL). The mixture was washed twice with saturated aqueous sodium bicarbonate solution and once with brine. The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo. The mixture was purified by silica gel column chromatography to obtain 1.55 g of 3-[(tert-Butyldimethylsilyl)oxy]-1-propanal with a yield of 82%.
![3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANAL synthesis route](/NewsImg/2025-06-30/6388687857118260082464429.png "3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANAL synthesis route")
| [Chemical Reactivity]
3-[(tert-Butyldimethylsilyl)oxy]-1-propanal is stable under normal conditions, it reacts with oxidizing agents.
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