| Identification | More | [Name]
2-METHYLPYRIDINE-3-BORONIC ACID | [CAS]
899436-71-6 | [Synonyms]
2-METHYL-3-PYRIDINYLBORONIC ACID
2-METHYLPYRIDINE-3-BORONIC ACID
2-PICOLINE-3-BORONIC ACID
2-Methyl-3-pyridineboronic acid
2-Methylpyridine-3-boronic acid 96%
2-Methylpyridin-3-ylboronic acid | [Molecular Formula]
C6H8BNO2 | [MDL Number]
MFCD07368825 | [Molecular Weight]
136.94 | [MOL File]
899436-71-6.mol |
| Questions And Answer | Back Directory | [Synthesis]
At -78°C, butyllithium (17 mL, 28 mmol) was added dropwise to a 50 mL 4/1 toluene/THF (4/1, 50 mL) solution of 3-bromo-2-methylpyridine (4.00 g, 23 mmol) and triisopropyl borate (6.40 mL, 28 mmol). The mixture was heated to -70°C over 30 minutes, then to 20°C. HCl (2 M) was added to bring the solution to pH 1. Water (20 mL) was then added, and the mixture was extracted with toluene. The aqueous layer was neutralized with 1 M NaOH and extracted with dichloromethane. The aqueous layer was concentrated to dryness, and the white solid was washed with dichloromethane. The combined organic layers were dried over sodium sulfate, filtered, and concentrated to give 2.10 g of a yellow, oily 2-methylpyridine-3-boronic acid. ES+ = 138.2 (M+H). | [Application]
2-Methylpyridine-3-boronic acid is an organic intermediate that can be prepared in one step from 3-bromo-2-methylpyridine and triisopropyl borate. 2-Methylpyridine-3-boronic acid can be used in the Suzuki reaction. |
| Chemical Properties | Back Directory | [Boiling point ]
303.6±44.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [form ]
solid | [pka]
4.08±0.58(Predicted) | [color ]
tan | [InChI]
InChI=1S/C6H8BNO2/c1-5-6(7(9)10)3-2-4-8-5/h2-4,9-10H,1H3 | [InChIKey]
TWKMYNQPIICYNV-UHFFFAOYSA-N | [SMILES]
B(C1=CC=CN=C1C)(O)O | [CAS DataBase Reference]
899436-71-6(CAS DataBase Reference) |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Tetranov Biopharm
|
| Telephone: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
| Company Name: |
Adamas Reagent, Ltd.
|
| Telephone: |
4006009262 13023226327 |
| Website: |
http://www.tansoole.com |
| Company Name: |
Shanghai Ennopharm Co., Ltd.
|
| Telephone: |
+86 (21) 6435-5022 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList13640/0_EN.htm |
|