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899947-07-0

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899947-07-0 Structure

899947-07-0 Structure
IdentificationBack Directory
[Name]

Urea, N-(3-chloro-4-methylphenyl)-N'-1H-indol-3-yl-
[CAS]

899947-07-0
[Synonyms]

STING-IN-7
Urea, N-(3-chloro-4-methylphenyl)-N'-1H-indol-3-yl-
[Molecular Formula]

C16H14ClN3O
[MOL File]

899947-07-0.mol
[Molecular Weight]

299.75
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

STING-IN-7 (compound 21) is a potent STING inhibitor with an IC50 of 11.5 nM. STING-IN-7 inhibits the phosphorylation of STING and interferon regulatory factor 3 (IRF3)[1].
[References]

[1] Po-Wei Chang, et al. Analysis of structure-activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors. Bioorg Med Chem. 2023 Oct 14:95:117502. DOI:10.1016/j.bmc.2023.117502
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