| Identification | Back Directory | [Name]
EC 3.1.1.8 | [CAS]
9001-08-5 | [Synonyms]
Protexia
BtChoEase
EC 3.1.1.8
EC: 3.1.1.8
E.C. 3.1.1.9
IUB: 3.1.1.8
CHOLINESTERASE
choline esterase
Cholinesterase II
Choline esterase II
PSEUDOCHOLINESTERASE
Benzoylcholinesterase
PSEUDOCHOLINEESTERASE
BUTYRYL CHOLINESTERASE
BUTYRYLCHOLINE ESTERASE
CHOLINESTERASE, BUTYRYL
Esterase, butyrylcholine
CHOLINE ESTERASE, BUTYRYL
ACYLCHOLINE ACYL-HYDROLASE
BUTYRYLCHOLINESTERASE, HUMAN
Cholinesterase, Equine Serum
Butyrylcholinesterase USP/EP/BP
Cholinesterase,from Horse Serum
Cholinesterase,butyryl(Horse seruM)
butyrylcholinesterase from human serum
butyrylcholine esterase F. horse serum
CHOLINESTERASE, BUTYRYL FROM HORSESERUM
Butyrylcholinesterase from equine serum
butyrylcholine esterase from horse serum
CHOLINESTERASE BUTYRYL FROM HUMAN SERUM
Butyrylcholine esterase from equine serum, lyophil.
BUTYRYLCHOLINE ESTERASE FROM HORSE SERUM, ~250 U/MG*
BUTYRYLCHOLINE ESTERASE F. HORSE SERUM, LYOPH., ~10 U/MG
BUTYRYL CHOLINESTERASE FROM HORSE SERUM LYOPHILIZED POWDER 0 °C
BUTYRYL CHOLINESTERASE FROM EQUINE SERUM FROM EQUINE SERUM -20 °C
Acylcholine acyl-hydrolase, Choline esterase, butyryl, Pseudocholinesterase
BUTYRYL CHOLINESTERASE FROM HORSE SERUM 4-10 UNITS/MG DRY WEIGHT FROM HORSE SERUM
BUTYRYL CHOLINESTERASE FROM HORSE SERUM (ACYLCHOLINE ACYL-HYDROLASE E.C. 3.1.1.8) LYOPHILIZED 0 °C | [EINECS(EC#)]
232-579-2 | [MDL Number]
MFCD00081455 |
| Hazard Information | Back Directory | [Uses]
Selective inhibition of BChE activity, Butyrylcholinesterase can be used in the detection of organophosphates.Its use in the treatment of organophosphate toxicity has been explored. It has been reported that the level of BChE in human blood correlates to the degree of protection against potentially toxic nerve agents.Cholinesterases have also been investigated for their role in Alzheimer’s disease.
| [Biological Functions]
Butyrylcholinesterase (BuChE) is found in plasma, the liver, and the kidney. Its activity is also inhibited by carbamate insecticides. BuChE is able to hydrolyze much larger substrates than AChE due to differences in their structure that allow BuChE to bind bulky ligands. The physiological role of BuChE is not completely understood, but it represents an important detoxification pathway for anticholinesterase compounds (Sultatos, 2006). | [General Description]
Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities. The enzyme is a tetrameric glycoprotein with four equal subunits (110 kDa each). It is also termed as pseudocholinesterase. It is produced in the liver. It is found in blood, the synapse of neuromuscular junctions and glia cells and axons of white matter. | [Biochem/physiol Actions]
Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities.BChE can, unlike AChE, efficiently hydrolyze larger esters of choline such as butyrylcholine and benzoylcholine. The enzyme is a tetrameric glycoprotein with four equal subunits (110 kDa each). The enzyme is activated by Ca2+ and Mg2+. The activity is constant over the pH range of 6.0-8.0. It is inhibited by betaine, nicotine, organophosphates, and carbamate. |
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