| Identification | Back Directory | [Name]
AMINE:OXYGEN OXIDOREDUCTASE [DEAMINATING] | [CAS]
9001-66-5 | [Synonyms]
SSAO
AOC3
Renalase
Tyraminase
VAP-1 human
MAO (enzyme)
E.C. 1.4.3.4
Spermine oxidase
TYRAMINE OXIDASE
Oxidase, monoamine
Tryptamine oxidase
Spermidine oxidase
Monoamine oxygenase
Serotonin deaminase
Epinephrine oxidase
Flavin amine oxidase
N1,N12-Diacetylspermine oxidase
amine oxidase, flavin-containing
tyramine oxidase from arthrobacter sp.
YRAMINE OXIDASE FROM ARTHROBACTER &
plasma amine oxidase from bovine plasma
AMINE:OXYGEN OXIDOREDUCTASE [DEAMINATING]
tyramine oxidase from arthrobacter*species
PLASMA AMINE OXIDASE FROM BOVINE PLASMA;PAO | [EINECS(EC#)]
232-623-0 | [Molecular Formula]
C7H15N2O6P | [MDL Number]
MFCD00131620 | [MOL File]
9001-66-5.mol | [Molecular Weight]
254.178 |
| Chemical Properties | Back Directory | [Definition]
An enzyme that is distributedwidely among animals. It inactivates a number ofbiogenic amines by catalyzing the oxidative deam-ination of these compounds. | [density ]
0.319[at 20℃] | [vapor pressure ]
0Pa at 25℃ | [storage temp. ]
2-8°C
| [form ]
lyophilized powder
| [color ]
White to off-white | [biological source]
human | [Water Solubility ]
102g/L at 30℃ | [LogP]
-3 at 23℃ | [CAS DataBase Reference]
9001-66-5 |
| Hazard Information | Back Directory | [Uses]
Monoamine oxidase (EC 1.4.3.4) is an enzyme composed of different polypeptides. Monoamine oxidation catalyzes the oxidative deamination of various biological amines in brain and peripheral tissues by producing hydrogen peroxide. Monoamine oxidase plays an important role in maintaining the regulation of synaptic transmission, emotional behavior and other brain functions[1][2]. | [Flammability and Explosibility]
Notclassified | [Biological Activity]
The protein VAP-1 (vascular adhesion protein-1) belongs to the group of semicarbazide sensitive amine oxidases (SSAO) th at catalyze the formation of reactive oxygen species. It is a unique adhesion molecule th at participates in inflammatory leukocyte recruitment in blood vessels. It functions in leukocyte extravasation to inflamed tissues. In the human eyeit has been associated with ocular inflammatory diseasessuch as uveitisage-related macular degenerationand diabetic retinopathy. Its expression has been observed to be altered in several diseasessuch as rheumatoid arthritisdiabetesand atherosclerosis. | [References]
[1] Shih JC, et al. Monoamine oxidase: from genes to behavior. Annu Rev Neurosci. 1999;22:197-217. DOI:10.1146/annurev.neuro.22.1.197
[2] Bortolato M, et al. Monoamine oxidase inactivation: from pathophysiology to therapeutics. Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1527-33. DOI:10.1016/j.addr.2008.06.002
[3] Youdim MB, et al. The therapeutic potential of monoamine oxidase inhibitors. Nat Rev Neurosci. 2006 Apr;7(4):295-309. DOI:10.1038/nrn1883 |
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