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90035-08-8

90035-08-8 Structure

90035-08-8 Structure
IdentificationBack Directory
[Name]

Flocoumafen
[CAS]

90035-08-8
[Synonyms]

STORM
stratgem
wl108366
Stratagen
FLOCUMAFEN
FLOCOUMAFEN
flocoumafene
aphthyl)coumarin
Storm(rodenticide)
flocoumafene (draft f-iso)
flocoumafen (bsi, draft e-iso)
l)phenyl)methoxy)phenyl)-1-naphthalenyl)-
Flocoumafen (mixture of isomers) PESTANAL
4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-(4-trifluoromethylbenzyloxy)phenyl)-1-n
2-hydroxy-3-[3-[4-[4-(trifluoromethyl)benzyl]oxyphenyl]tetralin-1-yl]chromone
2h-1-benzopyran-2-one,4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-((4-(trifluoromethy
4-Hydroxy-3-[1,2,3,4-tetrahydro-3-[4-(4-trifluormethylbenzyloxy)phenyl]-1-naphtyl]cumarin
4-Hydroxy-3-(1,2,3,4-tetrahydro-3-(4-(4-trifluoromethylbenzyloxy)phenyl)-1-naphthyl)coumarin
4-hydroxy-3-{1,2,3,4-tetrahydro-3-[4-(4-trifluoromethylbenzyloxy) phenyl] naphthyl} coumarin
3-(3-(4,4-Trifluoromethylbenzyloxyphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarin
2-Hydroxy-3-[3-[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]-1,2,3,4-tetrahydronaphthalen-1-yl]chromen-4-one
2H-1-Benzopyran-2-one, 4-hydroxy-3-1,2,3,4-tetrahydro-3-4-4-(trifluoromethyl)phenylmethoxyphenyl-1-naphthalenyl-
4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-((4-(trifluoromethyl)phenyl)methoxy)phenyl)-1-naphthalenyl)-2h-1-benzopyran-2-on
4-hydroxy-3-[1,2,3,4-tetrahydro-3-[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]-1-naphthalenyl]-2H-1-Benzopyran-2-one
4-Hydroxy-3-(1,2,3,4-tetrahydro-3-(4-((4-(trifluoromethyl)phenyl)methoxy)phenyl)-1-naphthalenyl)-2H-1-benzopyran-2-one
4-Hydroxy-3-[[1,2,3,4-tetrahydro-3-[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]naphthalen]-1-yl]-2H-1-benzopyran-2-one
A mixture of: cis-4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-(4-trifluoromethylbenzyloxy)phenyl)-1-naphthyl)coumarin trans-4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-(4-trifluoromethylbenzyloxy)phenyl)-1-naphthyl)coumarin
[EINECS(EC#)]

421-960-0
[Molecular Formula]

C33H25F3O4
[MDL Number]

MFCD01662724
[MOL File]

90035-08-8.mol
[Molecular Weight]

542.54
Chemical PropertiesBack Directory
[Melting point ]

181 °C
[Boiling point ]

672.4±55.0 °C(Predicted)
[density ]

1.2 g/cm3
[vapor pressure ]

1.33 x l0-10 Pa (25 °C)
[Fp ]

23 °C
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

neat
[pka]

4.50±1.00(Predicted)
[Water Solubility ]

1.1 mg l-1
[color ]

White to off-white
[InChIKey]

KKBGNYHHEIAGOH-UHFFFAOYSA-N
[EPA Substance Registry System]

2H-1-Benzopyran-2-one, 4-hydroxy-3-[1,2,3,4-tetrahydro-3-[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]-1-naphthalenyl]- (90035-08-8)
Hazard InformationBack Directory
[Uses]

Flocoumafen is a second generation anticoagulant rodenticide. Flocoumafen is extremely effective against strains of pest rodents resistant to conventional anticoagulants. Flocoumafen is highly toxic and is used strictly in sewers and indoors in some places such as UK.
[Definition]

ChEBI: Flocoumafen is a ring assembly, a member of naphthalenes and a member of benzenes.
[in vivo]

Flocoumafen (0.02-0.1 mg/kg, once a week for 14 weeks) accumulates residues in the liver of rats and cannot be completely metabolized, showing anticoagulant toxicity at high doses[3].

Animal Model:Male Fischer rats[3]
Dosage:0.02 and 0.1 mg/kg; once a week; for 14 weeks
Administration:Oral
Result:Caused noticeable cell accumulation in the liver, with residuals increasing as the dose rises at low doses, while at high doses, it stabilized after a while. The lethal anticoagulant effected only occurs when the binding sites were saturated.
Showed about 30% of the cumulative dosage disappeared from the feces within 3 days after each administration at low doses,for high doses, this value ranges from 18% after the first dose to 59% after the tenth dose, and anticoagulant toxicity appeared after six weeks.
[IC 50]

MMP-9; Glucocorticoid Receptor 2
[Metabolic pathway]

Flocoumafen exists as cis and trans isomers (Scheme 1). The tetralin ring adopts its most stable conformation in each case and the two forms have very similar shapes. Both are active rodenticides. The fate of flocoumafen in soils and plants has not been studied in detail because the compound is usually used as a pelleted bait or in a wax block. This limits its dissipation in the environment. Studies in animals and birds have been conducted as part of the assessment of safety and to investigate mode of action. Metabolism is slow in the rat and rapid in Japanese quail but this difference should be interpreted with care because of the 100-fold difference in dose used (see also Overview).
[Degradation]

Flocoumafen is a stable compound; no detectable degradation occurs at 50 °C at pH 7-9 over 4 weeks.
Safety DataBack Directory
[Hazard Codes ]

T+,N
[Risk Statements ]

26/27/28-48/23/24/25-50/53
[Safety Statements ]

28-36/37/39-45-60-61
[RIDADR ]

3027
[WGK Germany ]

3
[RTECS ]

DJ3100300
[HazardClass ]

6.1(a)
[PackingGroup ]

I
[Hazardous Substances Data]

90035-08-8(Hazardous Substances Data)
[Toxicity]

LD50 in rats, mice, rabbits (mg/kg): 0.25, 0.8, 0.2 orally (Bowler)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

p-Toluenesulfonic acid-->4-Hydroxycoumarin-->Warfarin-->1,2,3,4-Tetrahydronaphthalene-->1,2,3,4-Tetrahydro-1-naphthol
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Flocoumafen(90035-08-8).msds
Tags:90035-08-8 Related Product Information
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