| Identification | Back Directory | [Name]
EC 2.4.2.4 | [CAS]
9030-23-3 | [Synonyms]
TYMP
ECGF1
MNGIE
EC 2.4.2.4
Gliostatin
Phosphorylase,thymidine
THYMIDINE PHOSPHORYLASE
Thymidine Phosphorylase, recombinant
THYMIDINE PHOSPHORYLASE FROM*ESCHERICHIA COLI
ANTI-ECGF1 (CENTER) antibody produced in rabbit
THYMIDINE: ORTHOPHOSPHATE DEOXYRIBOSYLTRANSFERASE
THYMIDINE PHOSPHORYLASE, RECOMBINANT*FRO M E. COLI
thymidine:orthophosphate deoxy-d-ribosyltransferase
THYMIDINE PHOSPHORYLASE, ASEPTICALLY*FIL LED, FROM E
Thymidine Phosphorylase, recombinant from Escherichia coli
Thymidine Phosphorylase from Escherichia coli, Recombinant
Thymidine Phosphorylase, recombinant from Escherichia coli recombinant, expressed in E. coli, buffered aqueous solution, >=500 units/mL
Thymidine Phosphorylase, recombinant from Escherichia coli recombinant, expressed in E. coli, buffered aqueous solution, >=900 units/mL, aseptically filled
Thymidine Phosphorylase, recombinant from Escherichia coli recombinant, expressed in E. coli, Suitable for manufacturing of diagnostic kits and reagents, buffered aqueous solution, >=500 units/mL | [MDL Number]
MFCD00132426 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [form ]
buffered aqueous solution | [color ]
colorless to yellow | [biological source]
rabbit | [Water Solubility ]
soluble
water: soluble |
| Hazard Information | Back Directory | [Uses]
Thymidine phosphorylase has been used in a study to assess TAS-102 treatment in patients with advanced solid tumors. Thymidine phosphorylase has also been used in a study to investigate antitumor effects of the FP3 protein on patient-derived tumor tissue xenograft models of primary colon carcinoma. | [Uses]
Thymidine phosphorylase has been used in a study to evaluate biomarkers for advanced breast cancer patients treated with capecitabine-based first-line chemotherapy. Thymidine phosphorylase has also been used in a study to investigate implications for the clinical efficacy of nucleoside analogues. | [General Description]
Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation. | [Biochem/physiol Actions]
An enzyme that catalyzes the reversible conversion of thymidine to thymine. Thymidine phosphorylase is part of the pyrimidine nucleoside salvage pathway. This pathway allows pyrimidine bases to be recycled for nucleotide biosynthesis, while the pentose 1-phosphates are converted to intermediates of the pentose phosphate shunt and glycolysis. The E. coli thymidine phosphorylase shares 40% sequence homology with the human sequence, which has been found to be identical to the angiogenic agent platelet-derived endothelial growth factor. The purified E. coli enzyme has been shown to stimulate blood vessel growth in chick chorioallantoic membrane assays. |
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