| Identification | Back Directory | [Name]
Carbamic acid, N-[(1S)-1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-5-thiazolyl]-2-propyn-1-yl]-, methyl ester | [CAS]
903886-95-3 | [Synonyms]
A-908292
Carbamic acid, N-[(1S)-1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-5-thiazolyl]-2-propyn-1-yl]-, methyl ester | [Molecular Formula]
C18H20N2O4S | [MOL File]
903886-95-3.mol | [Molecular Weight]
360.43 |
| Hazard Information | Back Directory | [Uses]
A-908292 is a potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 of 23 nM for human ACC2. A-908292 can be used for the research of fatty acid metabolism[1][2]. A-908292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [in vivo]
A-908292 (30 mg/kg; p.o.; twice a day for 2 weeks) reduces serum glucose and triglyceride levels in ob/ob mice[2].
A-908292 (15 mg/kg; p.o.; twice a day for 4 days) markedly reduces plasma triglyceride levels in ACC2 knockout mice[3].
A-908292 (30-100 mg/kg; p.o.; twice a day for 3 days) stimulates the PPAR-α-dependent signaling pathway in rats[2]. | [References]
[1] Nishiura Y, et, al. Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2498-2503. DOI:10.1016/j.bmcl.2018.05.055
[2] Waring JF, et, al. Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway. J Pharmacol Exp Ther. 2008 Feb;324(2):507-16. DOI:10.1124/jpet.107.126938
[3] Takagi H, et, al. A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways. J Pharmacol Exp Ther. 2020 Mar;372(3):256-263. DOI:10.1124/jpet.119.263590 |
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