| Identification | Back Directory | [Name]
1H-Indole-3-acetamide, N-[1,1'-biphenyl]-2-yl-α-oxo- | [CAS]
906147-24-8 | [Synonyms]
PTK7/β-catenin-IN-1
1H-Indole-3-acetamide, N-[1,1'-biphenyl]-2-yl-α-oxo- | [Molecular Formula]
C22H16N2O2 | [MOL File]
906147-24-8.mol | [Molecular Weight]
340.37 |
| Hazard Information | Back Directory | [Uses]
PTK7/β-catenin-IN-1 (compound 01065) is a potent PTK7/β-catenin inhibitor with an IC50 of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research[1]. | [References]
[1] Laetitia Ganier, et al. Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer. ACS Chem Biol. 2022 May 20;17(5):1061-1072. DOI:10.1021/acschembio.1c00826 |
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