| Identification | Back Directory | [Name]
KPLH1130 | [CAS]
906669-07-6 | [Synonyms]
KPLH1130
3H-1,2,4-Triazol-3-one, 5-(2,4-dihydroxyphenyl)-2,4-dihydro-4-(4-methylphenyl)-
KPLH 1130,Pyruvate dehydrogenase kinase,PDH kinase,KPLH-1130,inhibit,Inhibitor,KPLH1130,PDHK | [Molecular Formula]
C15H13N3O3 | [MDL Number]
MFCD32067959 | [MOL File]
906669-07-6.mol | [Molecular Weight]
283.28 |
| Hazard Information | Back Directory | [Uses]
KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses. KPLH1130 improves glucose tolerance in HFD-fed mice[1]. | [References]
[1] Min BK, et al. Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype. Front Immunol. 2019 May 7;10:944. DOI:10.3389/fimmu.2019.00944 |
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