| Identification | Back Directory | [Name]
Fluxapyroxad | [CAS]
907204-31-3 | [Synonyms]
Xemium
907204-31-3
Fluxapyroxad
Fluxapyroxad@100 μg/mL in Acetonitrile
Fluxapyroxad@1000 μg/mL in Acetonitrile
Fluxapyroxad Solution in Acetonitrile, 100μg/mL
3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-...
3-(Difluoromethyl)-1-methyl-N-(3′,4′,5′-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide
3-(Difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)-1H-pyrazole-4-carboxamide
3-(DIFLUOROMETHYL)-1-METHYL-N-(3,4,5-TRIFLUORO-[1,1-BIPHENYL]-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE
1H-Pyrazole-4-carboxaMide, 3-(difluoroMethyl)-1-Methyl-N-(3',4',5'-trifluoro[1,1'-biphenyl]-2-yl)- | [Molecular Formula]
C18H12F5N3O | [MDL Number]
MFCD22373628 | [MOL File]
907204-31-3.mol | [Molecular Weight]
381.299 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
40-50/53 | [Safety Statements ]
36/37-60-61 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Acute 1
Aquatic Chronic 1
Carc. 2
Lact. |
| Hazard Information | Back Directory | [Chemical Properties]
Flumioxazin is white crystal, melting point 156.8℃, relative density 1.42 (room temperature), vapor pressure (25℃) >8.1×10-9 Pa. Its solubility at room temperature (g/L, 20℃): acetone >250, acetonitrile 167.6±0.2, methylene chloride 146.1±0.3, ethyl acetate 123.3±0.2, methanol 53.4, toluene 20.0, n-octanol 4.69, n-heptane 0.106. Kow logP is 3.08 (deionized water, 3.09 (pH 4), n-heptanol 0.106. 20.0, n-octanol 4.69, n-heptane 0.106. octanol/water partition coefficients (20°C) Kow logP were 3.08 (deionized water), 3.09 (pH 4), 3.13 (pH 7), 3.09 (pH 9). | [Uses]
Fluxapyroxad is a new generation carboxamide funugicide and its residues are found in food. Pesticide component. | [Definition]
ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 3-(difluoromethyl)-1-methylpyrazole-4-carboxylic acid with the amino group of 3',4',5'-trifluorobiphenyl-2-amine. Used to control a number of cereal fungal pathogens including those
elonging to the Ascomycetes, Basidiomycetes and Zygomycetes families. | [in vivo]
Fluxapyroxad (10 mg/kg/day, po via diet for 13 weeks) induces the body weight gain reduction, colon length reduction, intestinal barrier integrity impairment and proinflammatory cytokines secretion, inducing chronic colonic inflammation in C57BL/6 J mice[2].
| Animal Model: | C57BL/6 J mouse model[2]. | | Dosage: | 10 mg/kg/day | | Administration: | po via diet for 13 weeks | | Result: | Decreased body weight gain, shortened the colon length, damaged the colonic crypts, increased the levels of proinflammatory cytokines IL-6, IL-1β, and TNF-α, decreased the level of IL-22, impaired the intestinal barrier integrity. |
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