| Identification | Back Directory | [Name]
CARBOXYPEPTIDASE G | [CAS]
9074-87-7 | [Synonyms]
EC 3.4.19.9
Glucarpidase
CARBOXYPEPTIDASE G
γ-glutamyl hydrolase
GAMMA-GLUTAMYL HYDROLASE
Hydrolase, gamma-glutamyl
CARBOXYPEPTIDASE G FROM PSEUDOMONAS SP.
Native Pseudomonas sp. Carboxypeptidase G
carboxypeptidase G from pseudomonas sp. purificat
Carboxypeptidase G from Pseudomonas sp. lyophilized powder, >=3 units/mg protein | [EINECS(EC#)]
232-978-1 | [Molecular Formula]
Zn4+8 | [MDL Number]
MFCD00130719 | [MOL File]
9074-87-7.mol | [Molecular Weight]
261.56 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: soluble0.5mg/mL | [form ]
lyophilized powder | [Water Solubility ]
H2O: soluble 0.5mg/mL | [Specific Activity]
≥3units/mg protein |
| Hazard Information | Back Directory | [Uses]
Carboxypeptidase G from Pseudomonas sp., or γ-Glutamyl hydrolase, has been used in a study to assess the role of the putidaredoxin COOH-terminus in P-450cam (cytochrome m) hydroxylations. Carboxypeptidase G from Pseudomonas sp. has also been used in a study to investigate the effects of nitric oxide on pemetrexed cytotoxicity via NO?cGMP signaling in lung adenocarcinoma cells. | [Biochem/physiol Actions]
Carboxypeptidase G is a lysosomal, thiol-dependent protease, which progressively cleaves γ-glutamyl pteroyl poly-γ-glutamate yielding pteroyl-α-glutamate (folic acid) and free glutamate. It is considered highly specific for the γ-glutamyl bond, but not for the C-terminal amino acid of the leaving group. Molecular mass of this homodimer is approximately 90 kDa. The enzyme is activated by Zn2+ ions. |
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