| Identification | Back Directory | [Name]
(+/-)13-HDOHE | [CAS]
90780-53-3 | [Synonyms]
(±)13-HDHA
(+/-)13-HDOHE
(+/-)13-HDOHE
WOGJPWPLTMTIHQ-LPXZKAEXSA-N
13-HYDROXY DOCOSAHEXAENOIC ACID
(+/-)13-HYDROXY-4Z,7Z,10Z,14E,16Z,19Z-DOCOSAHEXAENOIC ACID
4,7,10,14,16,19-Docosahexaenoic acid, 13-hydroxy-, (4Z,7Z,10Z,14E,16Z,19Z)- | [Molecular Formula]
C22H32O3 | [MDL Number]
MFCD02262230 | [MOL File]
90780-53-3.mol | [Molecular Weight]
344.49 |
| Chemical Properties | Back Directory | [Boiling point ]
511.2±50.0 °C(Predicted) | [density ]
0.995±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml | [pka]
4.58±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
(±)13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra is shown to metabolize DHA to 13(R)-HDHA, presumably via the 11R-lipoxygenase activity. (±)13-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. | [References]
[1] Di Marzo, et al. Polyunsaturated-fatty-acid oxidation in Hydra: Regioselectivity, substrate-dependent enantioselectivity and possible biological role. Biochem. J. 300, 501-507 (1994). |
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