| Identification | Back Directory | [Name]
(+/-)8-HDOHE | [CAS]
90780-54-4 | [Synonyms]
(±)8-HDHA
(+/-)8-HDOHE
(+/-)8-HDOHE
(+/-)10-HDOHE
ZHBVYDMSPDDAKE-VTIZNUJUSA-N
8-HYDROXY DOCOSAHEXAENOIC ACID
10-HYDROXY DOCOSAHEXAENOIC ACID
(+/-)8-HYDROXY-4Z,6E,10Z,13Z,16Z,19Z-DOCOSAHEXAENOIC ACID
(+/-)10-HYDROXY-4Z,7Z,11E,13Z,16Z,19Z-DOCOSAHEXAENOIC ACID | [Molecular Formula]
C22H32O3 | [MDL Number]
MFCD02262237 | [MOL File]
90780-54-4.mol | [Molecular Weight]
344.49 |
| Chemical Properties | Back Directory | [Boiling point ]
506.9±38.0 °C(Predicted) | [density ]
0.995±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml | [pka]
4.53±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
(±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)8-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. | [Uses]
(±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)8-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. | [References]
[1] VanRollins, et al. Autooxidation of docosahexaenoic acid: Analysis of ten isomers of hydroxydocosahexaenoate. J. Lipid Res. 25(5), 507-517 (1984). |
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