| Identification | Back Directory | [Name]
(+/-)4-HDOHE | [CAS]
90906-40-4 | [Synonyms]
(±)4-HDHA
(+/-)4-HDOHE
(+/-)4-HDOHE
IFRKCNPQVIJFAQ-PQVBWYSWSA-N
4-HYDROXY DOCOSAHEXAENOIC ACID
(+/-)4-HYDROXY-5E,7Z,10Z,13Z,16Z,19Z-DOCOSAHEXAENOIC ACID
5,7,10,13,16,19-Docosahexaenoic acid, 4-hydroxy-, (5E,7Z,10Z,13Z,16Z,19Z)- | [Molecular Formula]
C22H32O3 | [MDL Number]
MFCD02262235 | [MOL File]
90906-40-4.mol | [Molecular Weight]
344.49 |
| Chemical Properties | Back Directory | [Boiling point ]
502.3±50.0 °C(Predicted) | [density ]
0.995±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml | [form ]
Liquid | [pka]
4.57±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
(±)4-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells also produces 4-HDHA. However, the enzymatic product is most likely the S-isomer. (±)4-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. | [Uses]
(±)4-HDHA (4-Hydroxy docosahexaenoic acid) is an autoxidation product of Docosahexaenoic acid (HY-B2167) (DHA). (±)4-HDHA is a PPARγ agonist, antidiabetic and anti-inflammatory agent[1][2]. | [IC 50]
PPARγ | [References]
[1] Yamamoto K, et al. 4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor gamma agonist alleviates the symptoms of DSS-induced colitis. Biochem Biophys Res Commun. 2008 Mar 14;367(3):566-72. DOI:10.1016/j.bbrc.2007.12.188
[2] Richard Louis Dunbar, et al. Lymph-releasing compositions of fatty acids and uses thereof for lymphatic incorporation and systemic disease treatment. Patent. WO2023146984. |
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| Company Name: |
amyjet
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4006800868;027-59626688 18771149750 |
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http://www.amyjet.com/ |
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