| Identification | Back Directory | [Name]
CYCLOPROPANESULFINIC ACID, SODIUM SALT | [CAS]
910209-21-1 | [Synonyms]
cyclopropanesulfinate
Sodium cyclopropylsulfite
Sodium Cyclopropanesulfinate
CYCLOPROPANESULFINIC ACID, SODIUM SALT | [Molecular Formula]
C3H5NaO2S | [MDL Number]
MFCD08276208 | [MOL File]
910209-21-1.mol | [Molecular Weight]
128.13 |
| Chemical Properties | Back Directory | [Melting point ]
245-248°C | [storage temp. ]
Inert atmosphere,Room Temperature | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C3H6O2S.Na.H/c4-6(5)3-1-2-3;;/h3H,1-2H2,(H,4,5);; | [InChIKey]
UQDAMACUKOYMTP-UHFFFAOYSA-N | [SMILES]
S(C1CC1)(O)=O.[NaH] |
| Hazard Information | Back Directory | [Uses]
Sodium Cyclopropanesulfinate is a general chemical reagent used in the synthesis of AMG 232 (A576560), a potent MDM2-P53 inhibitor for use as an anti-tumor agent. | [Synthesis]
Sodium cyclopropyl sulfite was prepared as follows: sodium sulfite (1.32 g, 1.1 mmol), sodium bicarbonate (1.6 g, 20.0 mmol) was dissolved in pure water (15 mL), and the reaction was stirred at 55 ° C for 10 min, then cyclopropylsulfonyl chloride (1.4 g, |
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