| Identification | Back Directory | [Name]
4SC-202 (free base) | [CAS]
910462-43-0 | [Synonyms]
CS-1285
Domatinostat
4SC-202 (free base)
(E)-N-(2-aminophenyl)-3-(1-(4-(1-methyl-1H-pyrazol-4-yl)phenylsulfonyl)-1H-pyrrol-3-yl)acrylamide
(2E)-N-(2-Aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-2-propenamide
2-Propenamide, N-(2-aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-, (2E)- | [Molecular Formula]
C23H21N5O3S | [MDL Number]
MFCD28155264 | [MOL File]
910462-43-0.mol | [Molecular Weight]
447.51 |
| Chemical Properties | Back Directory | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 58 mg/mL (129.61 mM) | [form ]
Solid | [pka]
12.60±0.70(Predicted) | [color ]
White to khaki |
| Hazard Information | Back Directory | [Uses]
4SC-202 acts as a selective and potent, orallly available inhibitor of histone deacetylases (HDAC) specific for class 1 HDAC isoenzymes with an IC50 value. | [in vivo]
Oral gavage of Domatinostat (4SC-202 free base) inhibits HT-29 xenograft growth in nude mice, and when combined with oxaliplatin, its activity is further strengthened[2]. | [IC 50]
HDAC-3: 0.57 μM (IC50); HDAC-2: 1.12 μM (IC50); HDAC-1: 1.2 μM (IC50); HDAC-11: 9.7 μM (IC50); HDAC-5: 11.3 μM (IC50); HDAC-10: 21 μM (IC50); HDAC-9: 50 μM (IC50) | [storage]
Store at -20°C |
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