| Identification | Back Directory | [Name]
4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one | [CAS]
910656-27-8 | [Synonyms]
MK-0633
Setileuton
Setileuton, 10 mM in DMSO
4-(4-fluorophenyl)-7-[[[5-[(2S)-1,1,1-trifluoro-2-hydroxybutan-2-yl]-1,3,4-oxadiazol-2-yl]amino]methyl]chromen-2-one
4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one
2H-1-Benzopyran-2-one, 4-(4-fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]- | [Molecular Formula]
C22H17F4N3O4 | [MDL Number]
MFCD16619367 | [MOL File]
910656-27-8.mol | [Molecular Weight]
463.38 |
| Hazard Information | Back Directory | [Uses]
Setileuton (MK-0633) is an inhibitor for 5-lipoxygenase, that inhibits the oxidation of arachidonic acid by recombinant human 5-LO, and the production of LTB4 in calcium ionophore-stimulated human whole blood, with IC50 of 3.9 and 52 nM, respectively[1]. | [in vivo]
Setileuton (5 mg/kg, i.v.; or 20 mg/kg, p.o., single dose) exhibits good pharmacokinetic profils with a half-time T1/2 of 3.3 h, and a bioavailability of 66% in rat model[1]. | [References]
[1] Ducharme Y, et al., The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor. ACS Med Chem Lett. 2010 Apr 13;1(4):170-4. DOI:10.1021/ml100029k |
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Alfa Chemistry
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+1 (201) 478-8534 |
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www.alfa-chemistry.com |
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