| Chemical Properties | Back Directory | [Boiling point ]
678.795±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.217±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
9.065±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
AZ760 is a CCR8 antagonist. AZ760 shows excellent potency, good lipophilicity and high free fraction in blood. AZ760 exhibits unacceptable hERG inhibition[1]. | [References]
[1] Connolly S, et al. Orally bioavailable allosteric CCR8 antagonists inhibit dendritic cell, T cell and eosinophil migration. Biochem Pharmacol. 2012 Mar 15;83(6):778-87. DOI:10.1016/j.bcp.2011.12.021 |
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