| Identification | Back Directory | [Name]
SLx-4090 | [CAS]
913541-47-6 | [Synonyms]
KD-026
SLx-4090
KD-026 913541-47-6
KD 026,microsomal triglyceride transfer protein,MTP inhibitor,inhibit,Inhibitor,enterocytic-specific,dyslipidemia
2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-6-[[[6-methoxy-4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-, phenyl ester | [Molecular Formula]
C31H25F3N2O4 | [MDL Number]
MFCD28502203 | [MOL File]
913541-47-6.mol | [Molecular Weight]
546.54 |
| Chemical Properties | Back Directory | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO: Sparingly soluble: 1-10 mg/mL
Ethanol: Slightly soluble: 0.1-1 mg/mL | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SLX-4090 is an orally active enterocytic-specific microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 8.0 nM. SLX-4090 can be used for the research of dyslipidemia[1]. | [in vivo]
SLX-4090 (orally, 30 mg/kg) reduces postprandial lipids by 50% with an ED50 value 7 mg/kg in rats[1]. | [References]
[1] Enoch Kim, et al. A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, SLx-4090: biochemical, pharmacodynamic, pharmacokinetic, and safety profile. J Pharmacol Exp Ther. 2011 Jun;337(3):775-85. DOI:10.1124/jpet.110.177527 |
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