| Identification | Back Directory | [Name]
Cazpaullone | [CAS]
914088-64-5 | [Synonyms]
Cazpaullone
MGQSIUXWCFOENX-UHFFFAOYSA-N
Cazpaullone
(9-Cyano-1-azapaullone) | [Molecular Formula]
C16H10N4O | [MDL Number]
MFCD18782605 | [MOL File]
914088-64-5.mol | [Molecular Weight]
274.28 |
| Hazard Information | Back Directory | [Description]
Cazpaullone is a glycogen synthase kinase-3 (GSK-3) inhibitor. Cazpaullone shows transient stimulation of the mRNA expression of the beta cell transcription factor Pax4, an important regulator of beta cell development and growth. Cazpaullone has potential as a starting point for developing agents for the treatment of diabetes. | [Uses]
Cazpaullone is a glycogen synthase kinase-3 (GSK-3) inhibitor. Cazpaullone can activate pancreatic beta cell protection and replication. Cazpaullone can be used for the research of diabetes[1]. | [References]
[1] Stukenbrock H, et al. 9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication. J Med Chem. 2008 Apr 10;51(7):2196-207. DOI:10.1021/jm701582f |
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