| Identification | Back Directory | [Name]
2H-Pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-trione, 5-[3-(1-methylcyclopropyl)propyl]- | [CAS]
915210-50-3 | [Synonyms]
SCH900271
SCH-900271
SCH 900271
SCH-900271, 10 mM in DMSO
2H-Pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-trione, 5-[3-(1-methylcyclopropyl)propyl]- | [Molecular Formula]
C14H16N2O4 | [MDL Number]
MFCD28502261 | [MOL File]
915210-50-3.mol | [Molecular Weight]
276.29 |
| Hazard Information | Back Directory | [Uses]
SCH-900271 is an orally active, potent nicotinic acid receptor (NAR) agonist with an EC50 of 2 nM in the hu-GPR109a assay. SCH-900271 exhibits dose-dependent inhibition of plasma free fatty acid (FFA). SCH-900271 has an improved therapeutic window to flushing[1]. | [References]
[1] Anandan Palani, et al. Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8. DOI:10.1021/ml200243g |
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