| Identification | Back Directory | [Name]
GP 2A | [CAS]
919077-81-9 | [Synonyms]
GP 2A
CP 2A
CB2 receptor agonist 3
CB2 receptor agonist 3,CB-2 receptor agonist 3
N-cyclohexyl-1-(2,4-dichlorophenyl)-6-methyl-4H-indeno[1,2-c]pyrazole-3-carboxamide
N-CYCLOHEXYL-1-(2,4-DICHLOROPHENYL)-1,4-DIHYDRO-6-METHYLINDENO[1,2-C]PYRAZOLE-3-CARBOXAMIDE
Indeno[1,2-c]pyrazole-3-carboxamide, N-cyclohexyl-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methyl- | [Molecular Formula]
C24H23Cl2N3O | [MDL Number]
MFCD09971118 | [MOL File]
919077-81-9.mol | [Molecular Weight]
440.36 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at RT | [solubility ]
Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
DMSO: Sparingly Soluble: 1-10 mg/ml | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GP 2A is a selective CB2 agonist that also shows modest agonism at CB1 receptors. | [Definition]
ChEBI: N-cyclohexyl-1-(2,4-dichlorophenyl)-6-methyl-4H-indeno[1,2-c]pyrazole-3-carboxamide is a member of pyrazoles and a ring assembly. | [Biological Activity]
Selective CB 2 receptor agonist; K i values are 7.6 and 900 nM for CB 2 and CB 1 receptors respectively. Increases P-ERK1/2 expression in HL-60 cells in vitro . | [References]
[1] GABRIELE MURINEDDU. Tricyclic Pyrazoles. 4. Synthesis and Biological Evaluation of Analogues of the Robust and Selective CB2 Cannabinoid Ligand 1-(2‘,4‘-Dichlorophenyl)-6-methyl-N-piperidin-1-yl- 1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide[J]. Journal of Medicinal Chemistry, 2006, 49 25: 7502-7512. DOI: 10.1021/jm060920d
[2] L. LUONGO . 1-(2′,4′-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice[J]. Neurobiology of Disease, 2010, 37 1: Pages 177-185. DOI: 10.1016/j.nbd.2009.09.021 |
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