| Identification | Back Directory | [Name]
CILAZAPRIL | [CAS]
92077-78-6 | [Synonyms]
Justor
Vascase
Initiss
Inhibace
CILAZAPRIL EPC(
ro31-2848monohydrate
cilazaprilmonohydrate
CILAZAPRIL EPC(CRM STANDARD)
Cilazapril Monohydrate (Inhibace)
hydrate,(1s-(1-alpha,9-alpha(r*)))-rbonyl)-3-phenylpropyl)amino)-10-oxo
6h-pyridazino(1,2-a)(1,2)diazepine-1-carboxylicacid,octahydro-9-((1-(ethoxyca
9[[1-ETHOXYCARBONYL-3-PHENYLPROPYL]AMINO]OCTAHYDRO-10-OXO-6HPYRIDAZINO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLIC ACID
(1s,9s)-9-[(s)-1-ethoxycarbonyl-3-phenylpropylamino]-10-oxoperhydropyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
9-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-10-oxo-1,2,3,4,6,7,8,9-oc tahydropyridazino[1,2-a]diazepine-1-carboxylic acid
(1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid hydrate
(1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}-1-hydroxy-10-oxo-octahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
(1S,9S)-9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, hydrate (1:1)
6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]aMino]octahydro-10-oxo-,hydrate (1:1), (1S,9S)-
[1S-[1α，9α(R^<*>^)]]-9-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1，2-α][1，2]diazepine-1-carboxylic acid monohydrate
CILAZAPRIL IMPURITY A1,1-DIMETHYLETHYL(1S,9S)-9-[[(S)-1-ETHOXYCARBONYL-3-PHENYLPROPYL]AMINO]-10-OXO-OCTAHYDRO-6H-PYRIDAZINO[1,2A][1,2]DIAZEPINE-1-CABOXYLATE EPC | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C22H33N3O6 | [MDL Number]
MFCD01692810 | [MOL File]
92077-78-6.mol | [Molecular Weight]
435.51 |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, crystalline powder. | [Melting point ]
98° (dec) | [alpha ]
D20 -62.51° (c = 1% in ethanol) | [storage temp. ]
Store at -20°C | [solubility ]
Slightly soluble in water, freely soluble in methanol and in methylene chloride. | [form ]
neat | [pka]
pKa1 3.3; pKa2 6.4(at 25℃) |
| Hazard Information | Back Directory | [Description]
Cilazapril is a new ACE inhibitor useful in the management of mild to moderate
hypertension. Orally administered cilazapril is a prodrug which is de-esterified to its
active diacid metabolite cilazprilat. Compared with enalapril and captopril, cilazapril is
more potent and longer lasting. | [Chemical Properties]
White or almost white, crystalline powder. | [Originator]
Hoffmann-LaRoche (Switzerland) | [Uses]
Antihypertensive. | [Definition]
ChEBI: Cilazapril monohydrate is a hydrate that is the monohydrate of cilazapril. It is used for the treatment of hypertension and heart failure. It has a role as an antihypertensive agent, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and a prodrug. It contains a cilazapril. | [Brand name]
Inhibace (Hoffmann-LaRoche). |
|
|