| Identification | Back Directory | [Name]
BAY 869766 | [CAS]
923032-38-6 | [Synonyms]
RDEA119 R enantiomer
BAY 869766 R enantiomer
RefaMetinib (R enantioMer)
RefaMetinib (RDEA-119, BAY 86-9766)
Refametinib (BAY 869766) R enantiomer
RDEA119; RDEA 119; BAY 86-9766; BAY 869766; BAY869766
N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2R)-2,3-dihydroxypropyl]cyclopropanesulfonamide | [Molecular Formula]
C19H20F3IN2O5S | [MDL Number]
MFCD20524892 | [MOL File]
923032-38-6.mol | [Molecular Weight]
572.34 |
| Chemical Properties | Back Directory | [Boiling point ]
566.9±60.0 °C(Predicted) | [density ]
1.82±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
15.54±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Refametinib R enantiomer is a MEK inhibitor extracted from patent WO2007014011A2, compound 1022, has an EC50 of 2.0-15 nM. | [IC 50]
MEK: 2-15 nM (EC50) | [References]
[1] Andreas Maderna, et al. N-(arylamino)-sulfonamide inhibitors of mek. WO 2007014011 A2. |
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