| Identification | Back Directory | [Name]
CRF (BOVINE) | [CAS]
92307-52-3 | [Synonyms]
CRH
CRF
CRF (BOVINE)
PubChem ID: 71581479
CRF (BOVINE) USP/EP/BP
Bovine ACTH-releasing factor
CORTICOTROPIN RELEASING FACTOR BOVINE
Cattle corticotropin-releasing horMone
Corticotropin-releasing factor (cattle)
Corticotropin Releasing Factor bovine,CRF, CRH
Corticotropin Releasing Factor bovine, ≥90% (HPLC)
CorticotropinReleasingFactorbovine,CorticotropinReleasingFactorbovin
SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-ASN-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2
H-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-ASN-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2
SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-ASN-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2 BOVINE | [Molecular Formula]
C206H340N60O63S | [MDL Number]
MFCD00081537 | [MOL File]
92307-52-3.mol | [Molecular Weight]
4697.33 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO | [form ]
Solid | [Sequence]
Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Asn-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2 |
| Hazard Information | Back Directory | [Uses]
CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM. | [Biochem/physiol Actions]
CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress. | [storage]
Store at -20°C | [Purification Methods]
The extract is purified by ion-exchange on CM-cellulose, desalted, evaporated and lyophilised. Then separate from impurities by gel filtration through Sephadex G-50. [Lande et al. Biochemical Preparations 13 45 1971, Esch et al. Biochem Biophys Res Commun 122 899 1984]. | [References]
[1] Hogg JE, et al. The human neuroblastoma cell line, IMR-32, expresses functional corticotropin-releasing factor receptors. Eur J Pharmacol. 1996 Sep 26;312(2):257-61. DOI:10.1016/0014-2999(96)00470-0
[2] Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35. DOI:10.1016/s0014-2999(99)00506-3
[3] Esposito P, et al. Corticotropin-releasing factor (CRF) can directly affect brain microvessel endothelial cells. Brain Res. 2003 Apr 11;968(2):192-8. DOI:10.1016/s0006-8993(03)02237-6 |
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