| | Identification | Back Directory |  | [Name] 
 2',6-DIHYDROXYFLAVONE
 |  | [CAS] 
 92439-20-8
 |  | [Synonyms] 
 2',6-DIHYDROXYFLAVONE
 6,2'-DIHYDROXYFLAVONE
 6,2'-Dihydroxyflavone
 2',6-DIHYDROXYFLAVONE
 6,2''-Dihydroxyflavone
 6-hydroxy-2-(2-hydroxyphenyl)chromen-4-one
 4H-1-Benzopyran-4-one, 6-hydroxy-2-(2-hydroxyphenyl)-
 6-hydroxy-2-(2-hydroxyphenyl)-4H-1-benzopyran-4-one,  DHF
 6,2'Dihydroxyflavone,Gamma-aminobutyric acid Receptor,γ-Aminobutyric acid Receptor,6,2'-Dihydroxyflavone,GABA Receptor,Inhibitor,inhibit,6,2' Dihydroxyflavone
 |  | [Molecular Formula] 
 C15H10O4
 |  | [MDL Number] 
 MFCD00017676
 |  | [MOL File] 
 92439-20-8.mol
 |  | [Molecular Weight] 
 254.24
 | 
 | Hazard Information | Back Directory |  | [Uses] 
 6,2''-Dihydroxyflavone, is a novel GABAA receptor antagonist.
 |  | [in vivo] 
 
 6,2'-Dihydroxyflavone-treated mice exhibit significant differences from control mice with respect to the percentage of open arms entries [F(4,73)=8.01, P<0.0001] and the percentage of time spent in open arms [F (4,73)=5.19, P<0.002], but not the number of entries to closed arms [F(4,73)= 0.79,P=0.54]. The post-hoc NewmaneKeuls’ tests confirm that 6,2'-Dihydroxyflavone significantly decreases the percentage of open arm entries and time spent in open arms at the doses of 8 and 16 mg/kg. 6,2'-Dihydroxyflavone treatment similarly increases step-through latency [F(4,75)=4.71, P<0.002], suggesting enhanced cognitive performance[1]. | 
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