| Identification | Back Directory | [Name]
α2C adrenoceptor agonist 1 | [CAS]
928115-79-1 | [Synonyms]
α2C adrenoceptor agonist 1
Urea, N-[3,4-dihydro-4-(1H-imidazol-5-ylmethyl)-2H-1,4-benzoxazin-6-yl]-N-ethyl-N′-methyl- | [Molecular Formula]
C16H21N5O2 | [MOL File]
928115-79-1.mol | [Molecular Weight]
315.37 |
| Chemical Properties | Back Directory | [Boiling point ]
670.302±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.286±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
13.115±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
α2C adrenoceptor agonist 1 (Compound A) is an orally active, highly selective, and non-central nervous system penetrating agonist for the α2C-adrenoceptor, with EC50 and Ki values of 108 nM and 12 nM, respectively. α2C adrenoceptor agonist 1 can be used in the study of nasal congestion[1]. | [in vivo]
α2C adrenoceptor agonist 1 (Compound A) (5 mg/kg; p.o.; single dose) exhibits poor brain permeability in Sprague-Dawley rats, with average values for Cmax, Tmax, and area under the curve being 0.8 μM, 0.7 h, and 2 μM?h, respectively[1]. | [IC 50]
Alpha-2C adrenergic receptor: 108 nM (EC50); Alpha-2C adrenergic receptor: 12 nM (Ki) | [References]
[1] Corboz MR, et al. Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A). J Pharmacol Exp Ther. 2011;337(1):256-266. DOI:10.1124/jpet.110.175794 |
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Biorbyt Ltd.
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http://www.biorbyt.com |
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