| Identification | Back Directory | [Name]
HPN-01 | [CAS]
928655-63-4 | [Synonyms]
HPN-01
HPN 01,HPN01
[1,1':3',1''-Terphenyl]-5'-carboxamide, 4'-amino-4''-(aminosulfonyl)-4-chloro- | [Molecular Formula]
C19H16ClN3O3S | [MDL Number]
MFCD32671867 | [MOL File]
928655-63-4.mol | [Molecular Weight]
401.87 |
| Chemical Properties | Back Directory | [Boiling point ]
564.3±60.0 °C(Predicted) | [density ]
1.425±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 10mg/mL | [form ]
Solid | [pka]
9?+-.0.10(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2[1]. | [IC 50]
IKK-α: 6.4 (pIC50); IKK-β: 7.0 (pIC50); IKK-ε: <4.8 (pIC50) | [References]
[1] Christopher JA, et al. The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-alpha and IKK-beta kinases. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3972-7. DOI:10.1016/j.bmcl.2007.04.088
[2] Ke Li, et al. Amino-aryl-benzamide compounds and methods of use thereof.WO2018204775A1. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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